Franck Kessie return to the starting XI for Milan, while Lazio look to Ciro Immobile and Felipe Anderson in this top of the table battle.
It kicks off at San Siro at 17.00 UK time (16.00 GMT).
You can follow all the build-up and action as it happens from today’s six Serie A games on the LIVEBLOG.
Liveblog: Serie A Wk3 Sunday
Both these teams have started the season with a perfect record and plenty of goals, particularly Maurizio Sarri’s men after thrashing Spezia 6-1.
That makes it an early potential title clash and a meeting between two of the most attack-minded sides in the league.
Ibrahimovic and Kessie are back after their injuries and go straight into the starting XI, but Olivier Giroud is left out after recovering from COVID-19 and Rade Krunic is injured.
Lazio are missing only Bobby Adekanye, as Manuel Lazzari returns to the bench following a calf issue.
Ciro Immobile leads the trident with Pedro and Felipe Anderson, plus Luis Alberto and Sergej Milinkovic-Savic in midfield.
Milan: Maignan; Calabria, Kjaer, Tomori, Theo Hernandez; Tonali, Kessie; Florenzi, Brahim Diaz, Leao; Ibrahimovic
Lazio: Reina; Marusic, Luiz Felipe, Acerbi, Hysaj; Milinkovic-Savic, Leiva, Luis Alberto; Pedro, Immobile, Felipe Anderson