Lorenzo Insigne has to shake things up as a centre-forward during Victor Osimhen’s ban, as Napoli reshuffle away to troubled Genoa.
It kicks off at the Stadio Luigi Ferraris, in the Marassi neighbourhood of Genoa, at 17.30 UK time (16.30 GMT).
You can follow all the build-up and action as it happens from today’s four Serie A matches on the LIVEBLOG.
Liveblog: Serie A Wk2 Sunday 2021-22
The Partenopei still managed to beat Venezia 2-0 in their opening fixture, despite having Osimhen sent off and Insigne missing a penalty.
With the Nigeria international appealing to have the two-match ban reduced so he can face Juventus, Insigne is chosen as a makeshift centre-forward flanked by Chucky Lozano and Matteo Politano.
Piotr Zielinski, Dries Mertens, Diego Demme and Faouzi Ghoulam are out injured.
Genoa were thrashed 4-0 by Inter last week and have been diving into the transfer market for reinforcements, but not many of them are available yet for coach Davide Ballardini.
That includes ex-Napoli defender Nikola Maksimovic, who only arrived yesterday.
Ex-Parma midfielder Hernani is pushed into a more advanced role supporting Caleb Ekuban.
Genoa: Sirigu; Biraschi, Vanheusden, Criscito; Ghiglione, Sturaro, Badelj, Cambiaso; Hernani, Ekuban
Napoli: Meret; Di Lorenzo, Manolas, Koulibaly, Mario Rui; Fabian Ruiz, Lobotka, Elmas; Politano, Insigne, Lozano