Zlatan Ibrahimovic, Olivier Giroud and Simon Kjaer will start on the bench for Milan, while Maurizio Sarri could replace Manuel Lazzari with Adam Marusic.
Milan and Lazio meet at San Siro at 17.00 UK time.
Stefano Pioli is expected to rotate his squad ahead of Wednesday’s Champions League clash against Liverpool at Anfield Road.
Therefore, Simon Kjaer will start on the bench with captain Alessio Romagnoli and Fikayo Tomori at the back.
Sandro Tonali will get the nod in midfield along with Franck Kessié, who makes his season debut. Ante Rebic will be the Rossoneri’s sole striker with Zlatan Ibrahimovic and Olivier Giroud on the bench.
Lazio’s Manuel Lazzari is not fully fit after sustaining a muscle injury before the international break, so Maurizio Sarri could replace him with Adam Marusic.
Ciro Immobile will start up front despite returning from international duty earlier with a slight injury.
Milan: Maignan; Calabria, Tomori, Romagnoli, Theo Hernandez; Tonali, Kessie; Florenzi, Diaz, Leao; Rebic.
Lazio: Reina; Marusic, Luiz Felipe, Acerbi, Hysaj; Milinkovic-Savic, Leiva, Luis Alberto; Pedro, Immobile, Felipe Anderson.