Atalanta look to Duvan Zapata, Matteo Pessina and Ruslan Malinovskyi for their opening Champions League trip to Europa League holders Villarreal.
It kicks off at the Estadio de la Ceramica at 20.00 UK time (19.00 GMT).
You can follow the build-up and action as it happens from this game and Malmo-Juventus on the LIVEBLOG.
Champions League Liveblog: Malmo-Juventus and Villarreal-Atalanta
La Dea are in the Champions League for the third year in a row, also the third season in their entire history, having become staples at the top level of European football under Gian Piero Gasperini.
They’ve started the campaign slowly in Serie A, scraping a 2-1 win over Torino in stoppages, held 0-0 by Bologna and losing at the weekend to Fiorentina.
Luis Muriel is out injured for several weeks, along with Hans Hateboer, so Duvan Zapata again leads the attack, this time with support from Pessina and Malinovskyi.
Josip Ilicic is still struggling with a back problem.
Davide Zappacosta is picked rather than Joakim Maehle at right-wing-back, with the ever-present Robin Gosens on the left.
Villarreal won the Europa League last season under specialist coach Unai Emery, beating Manchester United on penalties in the Final.
Gerard Moreno leads the attack with Boualye Dia and Pino in more of an attack-minded 4-3-3 formation.
Villarreal: Rulli; Foyth, Raul Albiol, Pau Torres, Pedraza; Parejo, Capoue, Trigueros; G Moreno, Dia, Pino
Villarreal bench: Asenjo, M Gaspar, Alcacer, V Iborra, Estupinan, Danjuma, A Moreno, Coquelin, Pena, Mandi, Moi Gomez
Atalanta: Musso; Toloi, Palomino, Djimsiti; Zappacosta, De Roon, Freuler, Gosens; Pessina; Malinovskyi, Duvan Zapata
Atalanta bench: Rossi, Sportiello, Maehle, Koopmeiners, Pezzella, Demiral, Scalvini, Miranchuk, Lovato, Ilicic, Pasalic, Piccoli
Ref: Turpin (FRA)