Liverpool are one of the clubs who are most affected with players jetting off around the world on international duty.
But while World Cup qualifiers will be the immediate priority for these players, attention at Anfield is firmly on the club’s next match.
Jurgen Klopp’s side face Leeds United on Sunday afternoon as they look to continue their impressive start to the new season.
The latest result was a 1-1 draw against Chelsea at Anfield and that match has given the club some injury concerns ahead of the clash with Jurgen Klopp’s side.
Here’s the latest on Liverpool’s injury list.
The Brazilian forward is facing a nervous wait after suffering a hamstring injury.
Firmino was recalled to the starting line-up for the clash with Chelsea at the end of August but was replaced in the first half of the match by Diogo Jota.
Discussing the injury after the game, Klopp said: “Serious? I don’t know. Serious enough to take him off? Yes.
“Bobby felt his hamstring, came over and told us and we had to prepare the change.
“Bobby is nobody who raises the hand when he doesn’t feel anything.
“It doesn’t look too serious but you never know before you have a scan and we will know tomorrow.”
Firmino is expected to undergo further tests and could be out of action for a couple of weeks as a result.
The promising midfielder is a doubt for the weekend’s match after pulling out of England under-21 duty.
Elliott suffered a knock against Chelsea which led him to return to Merseyside in order to fully recover from the blow ahead of the Premier League return.
Liverpool will be hoping that he’s fit to play some part against Leeds United.
The midfielder has been a notable absentee during Liverpool’s start to the season.
Jones was forced off with a head injury during the club’s pre-season clash with Osasuna which meant that he was subjected to a spell on the sidelines as part of the protocol regarding head injuries.
Since then the 20-year-old hasn’t featured for the Reds but could be back in contention for the clash with Leeds United after the international break.
James Milner suffered an unspecified injury during August which led him to miss the contests with Burnley and Chelsea.
As it stands it remains unclear just how serious the injury is.
Jurgen Klopp will be keeping a close eye on the knock and should provide an update later in the week.
The full-back is another player who has been ruled out of action through injury.
Williams was due to link up with the Wales national team for their upcoming international fixtures but had to drop out of the squad due to an unspecified blow.
It remains to be seen what the injury is and Liverpool will need to assess it ahead of the return of Premier League action.
The midfielder is one to watch after picking up a knock while on international duty.
Minamino withdrew from the Japan squad and therefore will not feature in their World Cup Qualifier against China on Tuesday.
The Liverpool Echo have revealed that the injury is not serious, but means he could be a doubt to face Leeds next weekend.